Board Thread:WARNING ALL USERS False Info\Spoilers/@comment-12634038-20131008035810/@comment-28196652-20171121180425

In most depictions Vampires are generally the superior species to an extent. In fact more often than not the Vampires opress the wolves, some lore even depicts them enslaving them. However with that being said, wolves are significantly superior to any vampire when they change. Even an Original in the Vampire Diaries universe would struggle to physically subdue a fully transformed werewolf. The "Alphas" in Teen Wolf all the capability to fully shift into a wolf, it's only because of the budget that they don't. It's much easier and a whole lot cheaper to use a little makeup, some classy sideburns, and contacts with cgi enhancements.

So I guess it would come down to a case by case basis.

Examples:

Damon vs. Derek, Outcome would most likely be Derek winning. Especially if he changed. Damon's only advantage is speed while their both still in "human form".

Stefan vs. Beta (any), Outcome would most likely be the death of the Beta. Although if the wolves in Teen Wolf share the "venom" that TVD wolves do, then Stefan could die shortly after the fight. Granted the Beta had the chance to bite him.

Baby Vamp vs. Beta, Could go either way. They're pretty equal.

Original vs. Alpha, The Original would almost certainly win eventually. But it would require them to exert a lot of force. Klaus specifically? It would be a bloodbath. Same with Marcel as The Beast.

PS: To throw another show into the mix. The Alphas from Supernatural would destroy just about anything from either opposing universe. Minus a few exceptions like The Originals of course.

PPS: Van Helsing's wolf form would absolutely demolish everything from all three universes, monster wise. Even Leviathans. The only exceptions would be Celestial beings, which don't really qualify as "monsters". IE, Angels, Demons, Ghosts, etc.