Board Thread:Legitimate Canon Questions/@comment-66.90.200.2-20140113085023/@comment-4091815-20140113114507

It seems to be a matter of how it is consumed.

We've seen the effects of inhaled powdered Wolfsbane twice.

Once, when Lydia blew it in Derek's face in Party Guessed and then again in Motel California.

In one instance it knocked Derek out and in the second it caused hallucinations. In this form we've only seen it cause symptoms in Werewolves.

Victoria Argent was unaffected by inhaling vaporized wolfsbane when she tried to kill Scott.

The imbibing of Wolfsbane by humans and werewolves alike in Party Guessed caused hallucinations.

Each was a different form of consumption eliciting different results with humans but consistently creating symptoms in werewolves.