Board Thread:False Info and Speculative Discussion/@comment-4554525-20151123020840/@comment-24989948-20151128073211

An idea that works to the idea is that each man has slaughtered an unknown amount of supernaturals (no number has been given and the only "supernatural' not a werewolf  Peter killed on screen was Jennifer Blake as far as I know) and took their power into their body.

In Peter's case in season 1 and this is highly speculative, Laura was a true alpha in the sense she inherited her mother's title and power when Talia died. Upon taking that power, he was unprepared for it and his  body reacted accordingly. When Derek stole the power from his uncle, the level of power was dimished, only giving Derek an amount of power enough to be an alpha, but no where near his mother, sister and uncle.

The ritual Kate applied to Derek making him younger (again, only speculation and I am not going to correct language) potentially reset his body, removing the time he had been an alpha. His loss of his wolf was a temporary side effect allowing his body to prepare for the next stage of his genetic inheritiance. Derek's character went through a fundamental change, perhaps opening the door to become an alpha again in a fashion Scott did.

As for another type of supernatural, Voodoo.

As the myth goes, Zeuz cursed Lycaon to be a wolf, the Gods are angered to see what has become of Lycaons progeny and send agents to rectify the problem.